He & She MD vs SynergenX Health
An in-depth comparison of two leading GLP-1 Providers
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He & She MD
Best for: starting below a standard dose, with microdose tiers
Visit He & She MD →
SynergenX Health
Best for: a published state list — 10 of 50 — when most of the register publishes none
Visit SynergenX Health →Two GLP-1 Providers chasing the same patients, trading off price, geography and what lands in the box differently. On our scoring, He & She MD opens cheaper — $99/mo against $150, and He & She MD finishes ahead, 9.3 to 5.1. What follows: the prices, what each plan actually covers, the six-dimension score, where each one is weak, and who should pick which.
Pricing
He & She MD
⛔ THIS ROW PREVIOUSLY DESCRIBED A "microdose" TIER THAT DOES NOT EXIST. Read live from heandshemd.com/weight-loss on 2026-08-14: the word "microdose" appears NOWHERE on the homepage or the weight-loss page. $99 is Semaglutide Injection, and its own asterisk reads "Price for purchase of 12 months supply" — a twelve-month prepay divided down, which is the LONGEST commitment the clinic sells, not the shortest. The figure was real; the product was invented. The standing month-to-month rate for injectable semaglutide is $199.
Injectable tirzepatide intro $199/mo (regular $289/mo)
SynergenX Health
Verbatim: 'Medication starts as low as $150 for one month of treatment' (compounded semaglutide). Includes medication per site ('SynergenX covers the full cost of your medication'). Initial telehealth consult $100 and follow-up visits $40/visit every 1–3 months billed separately. Dose-escalation tiers not disclosed.
What’s included
He & She MD
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
In the price
SynergenX Health
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Charged on top
Coaching
Charged on top
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
He & She MD
9.3/10
SynergenX Health
5.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | He & She MD | SynergenX Health |
|---|---|---|
| Starting Price | ✓$99/mo | $150/mo |
| Features | 8 features | 8 features |
| States Available | ✓50 | 10 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About He & She MD
GLP-1 Platinum opens at $139/month as an introductory rate on injectables, then settles at $199. That buys expedited delivery at no cost, board-certified clinicians reachable without limit, GLP-1 coaching and progress tracking inside the app, and billing only happens if a prescription is actually written. He & She MD works nationwide with doctor-prescribed compounded semaglutide and tirzepatide, injectable or oral, a microdose option, and access under brand names to Wegovy, Ozempic and Zepbound. Every state receives shipments except Louisiana. Certification is LegitScript.
Read our full He & She MD review →About SynergenX Health
A telehealth consultation at $100 comes first. After it, compounded semaglutide opens at $150/month with refrigerated shipping to the home and the drug both covered, and follow-ups cost $40 at intervals of 1-3 months. Texas patients are the only ones who can use the online program at present, though the chain itself spans 64 locations over 10 states doing hormone and weight-loss work. Counseling on nutrition and lifestyle, clinical support that continues, and dosing set for the individual are part of treatment.
Read our full SynergenX Health review →Pros & Cons
He & She MD
What we like
- Semaglutide at $99 a month, 48% below the $189 median for the same drug and form across this register
- Publishes a price on its own site before the medical questionnaire, so it can be compared without handing over health information
- The monthly figure covers medication, consult, shipping, coaching
- Coverage is published for all 50 states
- No FDA warning letter matched this operator when we searched our enforcement register
Watch-outs
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
SynergenX Health
What we like
- The monthly figure covers medication, consult, shipping
- No FDA warning letter matched this operator when we searched our enforcement register
- Baseline bloodwork is required before a prescription
Watch-outs
- No price appears until the medical intake is complete, so the cost cannot be compared before health information is submitted
- Billed separately from the monthly figure: labs, coaching
- Coverage is published for 10 states only, so this may not reach you
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
- Its semaglutide is compounded rather than FDA-approved, so it has not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
He & She MD takes it, 9.3 against 5.1, and it is especially strong on starting below a standard dose, with microdose tiers. SynergenX Health is no weak second and may fit you better on a published state list — 10 of 50 — when most of the register publishes none.
Choose He & She MD if…
You want starting below a standard dose, with microdose tiers and an opening price near $99 a month.
Choose SynergenX Health if…
You want a published state list — 10 of 50 — when most of the register publishes none and an opening price near $150 a month.
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Oak
Semaglutide at $119/month, 37% under the register median
From $119/mo
Get started →Direct Meds
Compounded semaglutide at $249/month
From $249/mo
Get started →Try Ageless
Semaglutide at $119/month, 37% under the register median
From $119/mo
Get started →He & She MD vs SynergenX Health: FAQ
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Novo Nordisk A/S owns the Wegovy®, Ozempic® and Rybelsus® marks; Eli Lilly and Company owns Mounjaro® and Zepbound®. Every other product name and mark on this page belongs to whoever owns it. No pharmaceutical manufacturer is affiliated with GLP Watchdog. See trademark disclaimer.