He & She MD vs Primary Clinic (Direct GLP)
An in-depth comparison of two leading GLP-1 Providers
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He & She MD
Best for: starting below a standard dose, with microdose tiers
Visit He & She MD →
Primary Clinic (Direct GLP)
Best for: seeing what it charges before you answer any medical questions
Visit Primary Clinic (Direct GLP) →Two GLP-1 Providers chasing the same patients, trading off price, geography and what lands in the box differently. On our scoring, Primary Clinic (Direct GLP) opens cheaper — $65/mo against $99, and He & She MD finishes ahead, 9.3 to 6.6. What follows: the prices, what each plan actually covers, the six-dimension score, where each one is weak, and who should pick which.
Pricing
He & She MD
⛔ THIS ROW PREVIOUSLY DESCRIBED A "microdose" TIER THAT DOES NOT EXIST. Read live from heandshemd.com/weight-loss on 2026-08-14: the word "microdose" appears NOWHERE on the homepage or the weight-loss page. $99 is Semaglutide Injection, and its own asterisk reads "Price for purchase of 12 months supply" — a twelve-month prepay divided down, which is the LONGEST commitment the clinic sells, not the shortest. The figure was real; the product was invented. The standing month-to-month rate for injectable semaglutide is $199.
Injectable tirzepatide intro $199/mo (regular $289/mo)
Primary Clinic (Direct GLP)
What’s included
He & She MD
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
In the price
Primary Clinic (Direct GLP)
Inclusions not disclosed.
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
He & She MD
9.3/10
Primary Clinic (Direct GLP)
6.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | He & She MD | Primary Clinic (Direct GLP) |
|---|---|---|
| Starting Price | $99/mo | ✓$65/mo |
| Features | ✓8 features | 4 features |
| States Available | ✓50 | 10 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About He & She MD
GLP-1 Platinum opens at $139/month as an introductory rate on injectables, then settles at $199. That buys expedited delivery at no cost, board-certified clinicians reachable without limit, GLP-1 coaching and progress tracking inside the app, and billing only happens if a prescription is actually written. He & She MD works nationwide with doctor-prescribed compounded semaglutide and tirzepatide, injectable or oral, a microdose option, and access under brand names to Wegovy, Ozempic and Zepbound. Every state receives shipments except Louisiana. Certification is LegitScript.
Read our full He & She MD review →About Primary Clinic (Direct GLP)
What is sold here is Direct Primary Care membership, not a GLP-1 package. $89/mo covers primary care without limit, texting the clinic directly, virtual visits the same day and routine labs. Members then purchase compounded 503A GLP-1s at wholesale, no markup applied: $65/mo and up for semaglutide, $110/mo and up for tirzepatide. It runs in 10 states so far, and monitoring of the medication happens inside a continuing care relationship.
Read our full Primary Clinic (Direct GLP) review →Pros & Cons
He & She MD
What we like
- Semaglutide at $99 a month, 48% below the $189 median for the same drug and form across this register
- Publishes a price on its own site before the medical questionnaire, so it can be compared without handing over health information
- The monthly figure covers medication, consult, shipping, coaching
- Coverage is published for all 50 states
- No FDA warning letter matched this operator when we searched our enforcement register
Watch-outs
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Primary Clinic (Direct GLP)
What we like
- Publishes a price on its own site before the medical questionnaire, so it can be compared without handing over health information
- No FDA warning letter matched this operator when we searched our enforcement register
Watch-outs
- Coverage is published for 10 states only, so this may not reach you
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
He & She MD takes it, 9.3 against 6.6, and it is especially strong on starting below a standard dose, with microdose tiers. Primary Clinic (Direct GLP) is no weak second and may fit you better on seeing what it charges before you answer any medical questions.
Choose He & She MD if…
You want starting below a standard dose, with microdose tiers and an opening price near $99 a month.
Choose Primary Clinic (Direct GLP) if…
You want seeing what it charges before you answer any medical questions and an opening price near $65 a month.
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Strut Health
Semaglutide at $99/month, 48% under the register median
From $99/mo
Get started →Oak
Semaglutide at $119/month, 37% under the register median
From $119/mo
Get started →Direct Meds
Compounded semaglutide at $249/month
From $249/mo
Get started →He & She MD vs Primary Clinic (Direct GLP): FAQ
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Novo Nordisk A/S owns the Wegovy®, Ozempic® and Rybelsus® marks; Eli Lilly and Company owns Mounjaro® and Zepbound®. Every other product name and mark on this page belongs to whoever owns it. No pharmaceutical manufacturer is affiliated with GLP Watchdog. See trademark disclaimer.