Best MOTS-c Providers in 2026: Ranked and Reviewed
Mice are where MOTS-c, a mitochondrial-derived peptide, has been studied as a metabolic regulator and “exercise mimetic.” Being direct here: no randomized trial in humans has ever put MOTS-c to the test as a weight-loss treatment, and no use of it holds FDA approval anywhere. Our full evidence review carries the detail. Since October 28, 2026, an interim HHS policy says HHS does not intend to take enforcement action against state-licensed 503A pharmacies that compound it as an injection under strict conditions, which does nothing to close that evidence gap. The current status is below.
16 providers compared
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16 MOTS-c providers compared · independently scored against our six-factor methodology.
Compare the top providers at a glance
Every row carries a logo, our editorial rating, price, the medications prescribed, and where the seller ships. Scan down a column and the list shortens fast.
- ★ Editor's Pick
single-ingredient MOTS-c by prescription (subcutaneous injection)
From /mo$200Coverage50 statesMedicationsBPC-157CJC-1295 / IpamorelinGHK-CuGlutathioneIpamorelinKPVMOTS-cNAD+TB-500Tesamorelin - Best Budget
single-ingredient MOTS-c by prescription (injection)
From /mo$109CoverageCheck intakeMedicationsBPC-157EpitalonGHK-CuKPVMOTS-cNAD+SemaxSermorelinTB-500 - Nationwide Coverage
single-ingredient MOTS-c by prescription (injection)
From /moCheck pricingCoverage50 statesMedicationsBPC-157EpitalonMOTS-cSemaxTB-500
Show 5 moreShow fewer
single-ingredient MOTS-c by prescription (subcutaneous injection)
From /moCheck pricingCoverage50 statesMedicationsBPC-157CJC-1295 / IpamorelinEpitalonGHK-CuGlutathioneMOTS-cNAD+retatrutideSemaxSermorelinTB-500single-ingredient MOTS-c by prescription (subcutaneous injection, intramuscular injection)
From /moCheck pricingCoverage45 states + DCMedicationsBPC-157EpitalonGlutathioneKPVMOTS-cNAD+SemaxSermorelinTB-500single-ingredient MOTS-c by prescription (injection)
From /moCheck pricingCoverage50 statesMedicationsBPC-157EpitalonGHK-CuGlutathioneGonadorelinKPVMOTS-cNAD+PT-141SemaxSermorelinTB-500Tesamorelinsingle-ingredient MOTS-c by prescription (subcutaneous injection)
From /moCheck pricingCoverageCheck intakeMedicationsBPC-157CJC-1295 / IpamorelinGHK-CuIpamorelinKPVMOTS-cSermorelinTB-500Tesamorelinsingle-ingredient MOTS-c by prescription (injection)
From /mo$195Coverage50 statesMedications5-Amino-1MQBPC-157CJC-1295CJC-1295 / IpamorelinDSIPEpitalonGHK-CuGlutathioneGonadorelinIpamorelinKPVMK-677MOTS-cNAD+PT-141SelankSemaxSermorelinTB-500TesamorelinThymosin Alpha-1
| Provider | Rating | From /mo | Medications | Coverage | |
|---|---|---|---|---|---|
★ Editor's Pick single-ingredient MOTS-c by prescription (subcutaneous injection) | $200 | BPC-157CJC-1295 / IpamorelinGHK-CuGlutathioneIpamorelinKPVMOTS-cNAD+TB-500Tesamorelin | 50 states | Visit → | |
Best Budget single-ingredient MOTS-c by prescription (injection) | $109 | BPC-157EpitalonGHK-CuKPVMOTS-cNAD+SemaxSermorelinTB-500 | Check intake | Visit → | |
Nationwide Coverage single-ingredient MOTS-c by prescription (injection) | Check pricing | BPC-157EpitalonMOTS-cSemaxTB-500 | 50 states | Visit → | |
 single-ingredient MOTS-c by prescription (subcutaneous injection) | Check pricing | BPC-157CJC-1295 / IpamorelinEpitalonGHK-CuGlutathioneMOTS-cNAD+retatrutideSemaxSermorelinTB-500 | 50 states | Visit → | |
 single-ingredient MOTS-c by prescription (subcutaneous injection, intramuscular injection) | Check pricing | BPC-157EpitalonGlutathioneKPVMOTS-cNAD+SemaxSermorelinTB-500 | 45 states + DC | Visit → | |
 single-ingredient MOTS-c by prescription (injection) | Check pricing | BPC-157EpitalonGHK-CuGlutathioneGonadorelinKPVMOTS-cNAD+PT-141SemaxSermorelinTB-500Tesamorelin | 50 states | Visit → | |
 single-ingredient MOTS-c by prescription (subcutaneous injection) | Check pricing | BPC-157CJC-1295 / IpamorelinGHK-CuIpamorelinKPVMOTS-cSermorelinTB-500Tesamorelin | Check intake | Visit → | |
 single-ingredient MOTS-c by prescription (injection) | $195 | 5-Amino-1MQBPC-157CJC-1295CJC-1295 / IpamorelinDSIPEpitalonGHK-CuGlutathioneGonadorelinIpamorelinKPVMK-677MOTS-cNAD+PT-141SelankSemaxSermorelinTB-500TesamorelinThymosin Alpha-1 | 50 states | Visit → |
All 16 providers on this board, in the order this board shows them
The comparison above shows the first 8. This is the full list the filter counts refer to, in the order this board shows them; each name opens that provider’s review.
A seller that shows no price until after the medical intake loses points on User Experience and Trust & Safety, and its review says so. How we score →
What this ranking checks
An interim HHS policy dated October 28, 2026 says HHS does not intend to take enforcement action against state-licensed pharmacies, federal facilities or licensed physicians that compound MOTS-c under set conditions, until a final rule settles whether MOTS-c goes on the 503A bulks list. The policy is interim enforcement discretion, and HHS’s Federal Register notice of October 30, 2026 calls it a draft that is not binding. It does not approve the peptide or add it to the 503A bulks list, it covers 503A pharmacies and physicians only (not 503B outsourcing facilities or research-use-only sellers), and HHS can narrow or withdraw it if safety or quality problems surface. The conditions: a patient-specific prescription; MOTS-c acetate as the only active ingredient, with no blends; subcutaneous or intramuscular injection only; the raw powder must be made at an FDA-registered plant and tested, on its certificate of analysis, for identity, strength, purity, endotoxin, microbes, heavy metals and other impurities; adverse events and quality problems go to FDA MedWatch; and the label must say the product is compounded and not for resale. None of this changes the evidence: no human trial has tested MOTS-c for weight loss.
What our ranking checks: that the seller's own website, read on November 5, 2026, offers MOTS-c as a single ingredient, by prescription, in a route the policy covers. Sellers whose pages offer it only in a blend, or in a form outside those routes, are not ranked.
What no website read can show: which 503A pharmacy fills the prescription, the certificate of analysis and the source of the raw powder, whether the label says the product is compounded and not for resale, whether adverse events are reported to FDA MedWatch, and which device comes with it. Ask the seller for those before you pay. Being ranked here is not a finding that a seller meets the policy.
What each seller’s own page showed on November 5, 2026
- Live VitalRoute: subcutaneous injectionPrice as listed: Starting at $200/mo (2-month subscription, $399 every 2 months)
- EnhancedRoute: injectionPrice as listed: $119 for 1 month; 3-month plan $327 billed every 3 months ($109/mo)
- AmbleRoute: injectionPrice as listed: $249/month
- ElitePhysiqMDRoute: subcutaneous injectionPrice as listed: $445.00–$929.00/month ($400.50–$836.10 with subscribe-and-save)
- New TidesRoute: subcutaneous injection, intramuscular injectionPrice as listed: not published
- PeptiRoute: injectionPrice as listed: $259/mo (10mg); $289 (20mg); $319 (30mg); $349 (50mg)
- GoalBMI WellnessRoute: subcutaneous injectionPrice as listed: not published
- Mankind HealthRoute: injectionPrice as listed: $195.00
- Scripts Rx DirectRoute: subcutaneous injectionPrice as listed: Injection 2 mg/mL: $189 for 1 month, $509 for 3 months ($170/mo)
- Primma WellnessRoute: subcutaneous injectionPrice as listed: $299 for 28 days, $449 for 56 days
- Guppy MedsRoute: subcutaneous injectionPrice as listed: MOTs-C 20mg Injectable: one-time $369, monthly auto-renew $339; also MOTs-C Tesamorelin blend $299 / $274
- RxPepsDirectRoute: subcutaneous injectionPrice as listed: $80 per 5mL vial (10mg total); a high-dose version is also listed
- California Trim ClinicRoute: subcutaneous injectionPrice as listed: not published
- BeyondMDRoute: subcutaneous injectionPrice as listed: $179 starting price
- HealthClinic MDRoute: injectionPrice as listed: not published
- LiveNow LongevityRoute: subcutaneous injectionPrice as listed: not published
Detailed Reviews
About the prices below: every dollar figure inside these provider summaries belongs to that clinic’s GLP‑1 weight-loss program. None is a MOTS-c price. For MOTS-c itself, read the price each seller’s own page listed, under “What this ranking checks” above. “Check pricing” in the tables means we hold no monthly figure for that seller that compares like for like, since many quote per vial, per capsule or per multi-month protocol.
Live Vital
Verified partnerBest for: single-ingredient MOTS-c by prescription (subcutaneous injection)
Live Vital is a Utah telehealth practice led by Dr. Patrick Taylor, MD, prescribing compounded semaglutide and tirzepatide next to a long peptide menu. The GLP-1s are sold as 10-week protocols paid upfront: $299 for semaglutide and $549 for tirzepatide, about $130 and $239 a month. The site advertises $99 and $183 a month instead. It serves all 50 states.
Score Breakdown
Pros
- ✓Semaglutide costs $130 a month, 35% below the $199 median for compounded semaglutide across the sellers we compare
- ✓Tirzepatide costs $239 a month, 11% below the $269 median for compounded tirzepatide across the sellers we compare
- ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
- ✓The monthly price includes the medication, clinician visits and shipping
- ✓Serves all 50 states
- ✓We found no FDA warning letters issued to Live Vital
Cons
- ✗Ask which pharmacy fills the prescription before you pay, so you can check its license
- ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Enhanced
Best for: single-ingredient MOTS-c by prescription (injection)
Enhanced is the consumer health line of Enhanced Group, the publicly traded company behind the Enhanced Games sports competition. Independent clinicians prescribe compounded semaglutide and tirzepatide through it, plus microdose plans from $59 a month on a 12-month plan, testosterone and peptides including BPC-157, TB-500, MOTS-c, KPV, epitalon and semax. Semaglutide costs $129 a month, or $89 a month on a 12-month plan paid up front; tirzepatide costs $169, or $129 on the same terms.
Score Breakdown
Pros
- ✓Semaglutide costs $129 a month, 35% below the $199 median for compounded semaglutide across the sellers we compare
- ✓Tirzepatide costs $169 a month, 37% below the $269 median for compounded tirzepatide across the sellers we compare
- ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
- ✓The monthly price stays the same as your dose goes up
- ✓The monthly price includes the medication, clinician visits and shipping
- ✓Names 4 pharmacies that fill its prescriptions, which most sellers do not
- ✓We found no FDA warning letters issued to Enhanced
Cons
- ✗Confirm it serves your state before you start the intake
- ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Amble
Best for: single-ingredient MOTS-c by prescription (injection)
Score breakdown, pros and cons
Amble Health, Inc. sells compounded semaglutide and tirzepatide online at one price for every dose, with supplies and shipping included. Semaglutide is $179 for a 1-month plan and tirzepatide $329, and the first month is $50 off. Longer plans cut the monthly rate to as low as $135 and $235, but they are charged in full up front and cannot be refunded once the order reaches the pharmacy.
Score Breakdown
Pros
- ✓Semaglutide costs $179 a month, 10% below the $199 median for compounded semaglutide across the sellers we compare
- ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
- ✓The monthly price stays the same as your dose goes up
- ✓The monthly price includes the medication, clinician visits and shipping
- ✓Serves all 50 states
- ✓We found no FDA warning letters issued to Amble
Cons
- ✗Tirzepatide costs $329 a month, 22% above the $269 median for compounded tirzepatide across the sellers we compare
- ✗Ask which pharmacy fills the prescription before you pay, so you can check its license
- ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
ElitePhysiqMD
Best for: single-ingredient MOTS-c by prescription (subcutaneous injection)
Score breakdown, pros and cons
ElitePhysiqMD, now at a new web address, sells compounded semaglutide at $219 for 4 weeks and tirzepatide from $249, rising with dose to $389. Each one-time order adds a $49 video visit and, after the first order, $30 shipping. Members pay 10% less per refill and no visit or shipping fees, but membership costs $89 a month. A board-certified internist, Hridayesh Nat, MD, is the named medical director.
Score Breakdown
Pros
- ✓Semaglutide costs $219 a month, close to the $199 median for compounded semaglutide across the sellers we compare
- ✓Tirzepatide costs $249 a month, 7% below the $269 median for compounded tirzepatide across the sellers we compare
- ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
- ✓The monthly price includes the medication, clinician visits and shipping
- ✓Serves all 50 states
- ✓We found no FDA warning letters issued to ElitePhysiqMD
- ✓A live video visit with a clinician is required before a prescription, which is slower than a form and is the more careful intake
Cons
- ✗Ask which pharmacy fills the prescription before you pay, so you can check its license
- ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
- ✗Its menu lists retatrutide, which FDA says cannot be used in compounding under federal law and has not been found safe and effective for any condition
New Tides
Best for: single-ingredient MOTS-c by prescription (subcutaneous injection, intramuscular injection)
Score breakdown, pros and cons
New Tides is a physician-led telehealth practice that prescribes compounded semaglutide and tirzepatide and may also prescribe nine peptides, including the six named in the October 2026 HHS peptide policy. Nothing is charged at sign-up: the card you save is charged only when a physician sends a prescription, and there is no subscription. Semaglutide is $200 and tirzepatide $250 per prescription, the same at every dose, with the physician visit, medication and shipping included.
Score Breakdown
Pros
- ✓Semaglutide costs $200 a month, close to the $199 median for compounded semaglutide across the sellers we compare
- ✓Tirzepatide costs $250 a month, 7% below the $269 median for compounded tirzepatide across the sellers we compare
- ✓Shows its price before the medical questionnaire, so you can compare it without handing over health information
- ✓The monthly price includes the medication, clinician visits and shipping
- ✓Serves 45 states and DC
- ✓We found no FDA warning letters issued to New Tides
Cons
- ✗Ask which pharmacy fills the prescription before you pay, so you can check its license
- ✗Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
How we rank, and what counts as “legit”
Scoring for every provider on this page runs against our published six-factor rubric[1]: value, effectiveness, user experience, trust & safety, accessibility and support.
Each of Wegovy, Zepbound, Ozempic and Mounjaro holds its own separate FDA approval under its own NDA number[4][5]. Published Phase 3 efficacy for semaglutide at 2.4 mg (~14.9% mean weight loss across 68 weeks) comes from STEP 1[6]; those for tirzepatide (~20.9% at the 15 mg dose over 72 weeks) come from SURMOUNT-1[7]. In 2025 the SURMOUNT-5 head-to-head set the two against each other[8].
How much of an anti-obesity medication is covered varies widely between state Medicaid programs and between commercial plans[9][10]. Under IRS Publication 502, compounded GLP-1s and brand-name ones alike are generally FSA/HSA eligible where a prescription exists[11].
Frequently Asked Questions
Sources & methodology — as of November 2026
- 1.GLP Watchdog — GLP-1 Pricing Index 2026 (our independent dataset)— GLP Watchdog.
- 2.FDA — Compounding and the 503A Pharmacy Framework— U.S. Food & Drug Administration.
- 3.FDA — Drug Shortages Database (current shortage listings)— U.S. Food & Drug Administration.
- 4.FDA — Wegovy (semaglutide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 5.FDA — Zepbound (tirzepatide) Approval History via Drugs@FDA— U.S. Food & Drug Administration.
- 6.STEP 1 Trial — Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding JPH et al.)— New England Journal of Medicine.PMID: 33567185.
- 7.SURMOUNT-1 Trial — Tirzepatide Once Weekly for the Treatment of Obesity (Jastreboff AM et al.)— New England Journal of Medicine.PMID: 35658024.
- 8.SURMOUNT-5 Trial — Tirzepatide vs. Semaglutide Head-to-Head in Obesity (Aronne LJ et al.)— New England Journal of Medicine.PMID: 40353578.
- 9.KFF — Medicaid coverage research (anti-obesity & GLP-1 drug policy)— Kaiser Family Foundation.
- 10.CMS — Medicaid prescription drug coverage policy (state-by-state)— Centers for Medicare & Medicaid Services.
- 11.IRS Publication 502 — Medical and Dental Expenses (HSA/FSA eligibility)— Internal Revenue Service.