Onyx Weight Loss vs Lean Meds
An in-depth comparison of two leading GLP-1 Providers
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Onyx Weight Loss
Best for: starting below a standard dose, with microdose tiers
Visit Onyx Weight Loss →
Lean Meds
Best for: knowing which pharmacy fills the vial — it names Belmar Pharmacy
Visit Lean Meds →Two GLP-1 Providers chasing the same patients, trading off price, geography and what lands in the box differently. On our scoring, Lean Meds opens cheaper — $79/mo against $99, and Lean Meds finishes ahead, 9.3 to 8.3. What follows: the prices, what each plan actually covers, the six-dimension score, where each one is weak, and who should pick which.
Pricing
Onyx Weight Loss
Verbatim: 'Starting at $228/month' (GLP-1 Agonist plan). Includes medication and supplies shipped to home. Entry tier only; higher-dose pricing not disclosed.
Verbatim: 'Starting at $280/month' (GLP-1/GIP Agonist plan). Includes medication and supplies. Entry tier only; specific drug name inferred from GLP-1/GIP dual agonist designation.
Verbatim: '$99/MONTH' (GLP-1 Microdosing plan). Low-dose gradual-start option.
Lean Meds
Standing month-to-month rate. The advertised $69 is the 12-month prepay tier; 3-month is $76 and 6-month is $73.
Standing month-to-month rate. Prepay tiers: $105 for 3 months, $100 for 6, $95 for 12.
What’s included
Onyx Weight Loss
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Lean Meds
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Onyx Weight Loss
8.3/10
Lean Meds
9.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Onyx Weight Loss | Lean Meds |
|---|---|---|
| Starting Price | $99/mo | ✓$79/mo |
| Features | ✓8 features | 7 features |
| States Available | 8 | ✓50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Onyx Weight Loss
GLP-1 (semaglutide-type) plans begin at $228/month; GLP-1/GIP (tirzepatide-type) plans at $280/month. There is also a $99/month GLP-1 microdosing option for anyone wanting a gradual-titration start. Onyx Weight Loss runs a nurse-practitioner-led telehealth clinic out of Mooresville, NC, set up by Madalyn Vangile RN and Tasha Vangile FNP-C, and it covers 8 states with HRT and peptides sold beside the GLP-1s. Its partner Strive Pharmacy ships medication and supplies home.
Read our full Onyx Weight Loss review →About Lean Meds
Titrating up does not raise the rate, which is flat and monthly: $79 to start on compounded semaglutide, $109 on compounded tirzepatide, the telehealth visit and shipping absorbed into both. Clinicians come from the OpenLoop Health network. Trinity HealthCare Supply, LLC operates the service and puts names to its five dispensing pharmacies as well as to the physicians who prescribe.
Read our full Lean Meds review →Pros & Cons
Onyx Weight Loss
What we like
- Semaglutide at $99 a month, 48% below the $189 median for the same drug and form across this register
- Publishes a price on its own site before the medical questionnaire, so it can be compared without handing over health information
- The monthly figure covers medication, consult, shipping
- No FDA warning letter matched this operator when we searched our enforcement register
Watch-outs
- Coverage is published for 8 states only, so this may not reach you
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Lean Meds
What we like
- Semaglutide at $79 a month, 58% below the $189 median for the same drug and form across this register
- Tirzepatide at $109 a month, 59% below the $267 median for the same drug and form across this register
- Publishes a price on its own site before the medical questionnaire, so it can be compared without handing over health information
- The monthly price is recorded as flat across doses, so it does not climb as the dose is titrated up
- The monthly figure covers medication, consult, shipping
- Coverage is published for all 50 states
- Names 5 dispensing pharmacies, which most sellers in this register do not do
- No FDA warning letter matched this operator when we searched our enforcement register
Watch-outs
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Lean Meds takes it, 9.3 against 8.3, and it is especially strong on knowing which pharmacy fills the vial — it names Belmar Pharmacy. Onyx Weight Loss is no weak second and may fit you better on starting below a standard dose, with microdose tiers.
Choose Onyx Weight Loss if…
You want starting below a standard dose, with microdose tiers and an opening price near $99 a month.
Choose Lean Meds if…
You want knowing which pharmacy fills the vial — it names Belmar Pharmacy and an opening price near $79 a month.
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Trimi Health
Knowing which pharmacy fills the vial — it names VialsRx
From $99/mo
Get started →Strut Health
Semaglutide at $99/month, 48% under the register median
From $99/mo
Get started →Oak
Semaglutide at $119/month, 37% under the register median
From $119/mo
Get started →Onyx Weight Loss vs Lean Meds: FAQ
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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