← Drug-vs-drug verdicts

Saxenda vs Foundayo: Daily Needle or Daily Pill

Saxenda (liraglutide, Novo Nordisk) vs Foundayo (orforglipron, Eli Lilly)

Last verified May 2026

By Ruth Calder · Enforcement Editor
Editorially reviewed & fact-checked against primary sources · How we verify contentLast reviewed

The verdict

Both are taken every day; only one requires an injection. SCALE Obesity reported about −8.0% at 56 weeks for Saxenda, ATTAIN-1 −11.1% at 72 weeks for Foundayo. The commercial picture is one-sided: Saxenda lists near $1,400 with no manufacturer cash-pay program, and Foundayo arrives with LillyDirect pricing pending. For a daily-dosing patient with no strong reason to inject, the pill is the more obvious starting conversation.

Side-by-side comparison

FieldSaxendaFoundayo
RouteDaily subcutaneous injection (prefilled pen)Daily oral tablet
Dosing schedule0.6 -> 1.2 -> 1.8 -> 2.4 -> 3.0 mg daily (5-step weekly titration)0.8 -> 2.5 -> 5.5 -> 9 -> 14.5 -> 17.2 mg daily (6-step titration)
MechanismPeptide GLP-1 receptor agonistNon-peptide small-molecule GLP-1 receptor agonist
Weight loss (obesity pivotal)~-8.0% / 56 wk (SCALE Obesity, 3.0 mg)-11.1% / 72 wk (ATTAIN-1, 17.2 mg)
How each compares against weight-labeled semaglutide-6.4% at 68 weeks when measured directly against it (STEP-8)Never tested against it — its trials were run separately
Whether food gets in the wayNone — inject any time of dayNone — swallow it whenever, with or without food
What it is approved to treatLong-term weight management in adults, and in adolescents from 12Long-term weight management in adults only. It holds no diabetes indication — that filing is still pending
Youngest approved age12 and over, at a BMI matching the adult obesity thresholdAdults only
What it costs if you pay cashAbout $1,400/mo retail, with no manufacturer cash programDirect-pay pricing was still pending at its 2026 launch

What each one costs in the compounded market

Standing monthly cash prices from the 556 sellers on this register. These are compounded preparations, not the approved products compared above.

Saxendaliraglutide

from $160 /mo

3 sellers publish a standing price; the median is $214 a month.

Foundayoorforglipron

from $149 /mo

2 sellers publish a standing price; the median is $149 a month.

⚠ A compounded preparation is not the approved product. No agency has reviewed that specific preparation for safety, effectiveness or manufacturing quality, and the legal ground under compounding these molecules narrowed when the shortages closed. The price gap is real, and so is the difference in oversight. Every seller, with its price record.

Frequently asked questions

Which works better for weight loss, Saxenda or Foundayo?

Saxenda recorded ~-8.0% / 56 wk (SCALE Obesity, 3.0 mg); Foundayo recorded -11.1% / 72 wk (ATTAIN-1, 17.2 mg). ⚠ These come from separate trials with different protocols and populations, so the gap between two numbers from two studies is weaker evidence than it looks. No head-to-head trial of this pair is on record here.

Are Saxenda and Foundayo the same drug?

No. Saxenda is liraglutide and Foundayo is orforglipron — different molecules, and they work differently: Peptide GLP-1 receptor agonist against Non-peptide small-molecule GLP-1 receptor agonist. Results with one do not predict results with the other.

Is Saxenda or Foundayo cheaper?

On the manufacturers' own cash pricing: Saxenda at About $1,400/mo retail, with no manufacturer cash program, Foundayo at Direct-pay pricing was still pending at its 2026 launch. ⚠ That is the list-price comparison, and it is not what most people pay. What you actually pay depends on whether your plan covers it, which formulary tier it sits in, and whether you have met your deductible — and for many people the honest comparison is between an insured copay and a cash-pay compounded alternative rather than between these two figures.

How is each one taken?

Saxenda: 0.6 -> 1.2 -> 1.8 -> 2.4 -> 3.0 mg daily (5-step weekly titration). Foundayo: 0.8 -> 2.5 -> 5.5 -> 9 -> 14.5 -> 17.2 mg daily (6-step titration). Worth weighing honestly against your own habits — the best drug for you is partly the one you will still be taking in eight months, and a dosing routine that does not fit a life gets abandoned.

What does a compounded version of each actually cost?

Across the 556 sellers in this register, the cheapest standing monthly cash prices we hold are liraglutide from $160 a month and orforglipron from $149 a month. ⛔ A compounded preparation is not the approved product: no agency has reviewed that specific preparation for safety, effectiveness or manufacturing quality, and the legal ground under compounding these molecules narrowed once the shortages closed. The price gap is real and so is the difference in oversight.

Can I switch from Saxenda to Foundayo?

Yes, with a prescriber. Expect to re-titrate from the bottom of the new drug's ladder rather than starting where you left off: these are different molecules and tolerance to one does not transfer to the other. Both the old drug's washout and the new drug's schedule apply.

Which one should I ask for?

That is a prescriber's call, and anyone answering it from a table is guessing. What a page like this can do is tell you what the trials measured, what the manufacturers charge, and where the evidence is still missing, so the conversation starts from the record rather than from an advertisement.

References

  1. 1.Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, et al. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management (SCALE Obesity and Prediabetes). N Engl J Med. 2015. PMID: 26132939.
  2. 2.Wharton S, Aronne LJ, Le Roux CW, et al. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, for Adults with Obesity (ATTAIN-1). N Engl J Med. 2025. PMID: 40960239.
  3. 3.Rubino DM, Greenway FL, Khalid U, O'Neil PM, Rosenstock J, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes (STEP 8). JAMA. 2022. PMID: 35015037.
  4. 4.Novo Nordisk. SAXENDA (liraglutide) injection — Prescribing Information. DailyMed (NIH/NLM). 2025. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3946d389-0926-4f77-a708-0acb8153b143
  5. 5.Eli Lilly and Company. FOUNDAYO (orforglipron) tablet — Prescribing Information. DailyMed (NIH/NLM). 2026. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8ac446c5-feba-474f-a103-23facb9b5c62

Related comparisons

See the full drug-vs-drug verdict index or provider rankings.