24hrDOC vs PlushCare
24hrDOC and PlushCare both sell semaglutide and tirzepatide; this is how their prices, coverage and records differ.
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PlushCare
Best for: coverage in all 50 states, which most sellers will not confirm
Visit PlushCare →If you are choosing between 24hrDOC and PlushCare, price alone will not settle it. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. 24hrDOC leads our six-part score, 7.1 to 6.4. One of the two has an FDA warning letter on record, covered below.
24hrDOC vs PlushCare price
24hrDOC and PlushCare start at the same figure, $149 a month, so the entry price does not separate them. Look at what each price covers and at the per-drug prices below.
Drug by drug: Semaglutide costs the same at both, $149 a month; tirzepatide is cheaper at 24hrDOC ($239 a month vs $399 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections.
Where each one treats patients
24hrDOC does not publish where it ships, and PlushCare lists 50 states.
Pricing
24hrDOC
Tirzepatide $239/mo sale (regular $339/mo); semaglutide $149/mo
PlushCare
Range up to $299/mo
Range up to $599/mo
What each price covers
24hrDOC's price also covers the clinician visit, the medication itself and shipping, which PlushCare does not claim.
24hrDOC is silent on lab work and coaching.
PlushCare is silent on shipping and coaching.
That matters most for the drug: unless PlushCare confirms otherwise, budget for medication on top of its listed price.
24hrDOC
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
PlushCare
Covered by the monthly price
Medication
Charged on top
Clinician visits
Charged on top
Shipping
Not stated
Lab work
Charged on top
Coaching
Not stated
Where each one scores higher
Overall, 24hrDOC scores 7.1 and PlushCare 6.4 out of 10.
24hrDOC is stronger on value (6.6 vs 3.0), user experience (8.0 vs 7.0) and support (7.0 vs 0.0).
PlushCare is stronger on trust & safety (7.5 vs 3.5) and accessibility (10.0 vs 5.0).
Effectiveness is within half a point.
24hrDOC
7.1/10
PlushCare
6.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
The FDA sent 24hrDOC a warning letter dated February 20, 2026 (letter 717984), and it is still open.
PlushCare has no FDA warning letter on record with us.
Features & Coverage
| Feature | 24hrDOC | PlushCare |
|---|---|---|
| Starting Price | $149/mo | $149/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | 1 letter | ✓None |
About 24hrDOC
Knock 100 dollars off a first order at 24hrDOC and the compounded GLP-1 semaglutide lands around 149 dollars per month, against a standing 249; doses step from 0.25 mg up to 2 mg. Oral semaglutide tablets and tirzepatide are also stocked, cash only, with insurance refused and operating 24/7. Speed is the whole pitch: roughly a 10-minute assessment, about 45 minutes to a prescription, messaging without limit, and discreet parcels out of licensed pharmacies. Which states it covers is not listed anywhere online.
Read our full 24hrDOC review →About PlushCare
PlushCare is an established virtual primary-care telehealth platform and a subsidiary of Transcarent, Inc., a Delaware corporation that also owns Accolade, 2nd.MD, and 98point6 by Transcarent. Virtual visits with US board-certified physicians cost $30 per appointment insured and $129 self-pay. GLP-1 prescribing is a clinician-discretionary option within the broader primary-care relationship.
Read our full PlushCare review →Pros & Cons
24hrDOC
What we like
- Semaglutide costs $149 a month, 19% below the $185 median for compounded semaglutide across the sellers we compare
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits and shipping
Watch-outs
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- The FDA has issued 24hrDOC a warning letter. Read what it alleges: a letter flags a problem but does not by itself rule a seller out
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
PlushCare
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- Serves all 50 states
- We found no FDA warning letters issued to PlushCare
- A live video visit with a clinician is required before a prescription, which is slower than a form and is the more careful intake
- Baseline bloodwork is required before a prescription
Watch-outs
- Not included in the monthly price: medication, clinician visits, lab work
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
24hrDOC wins this one, 7.1 to 6.4, above all for an oral route if you will not self-inject. PlushCare fits better if coverage in all 50 states, which most sellers will not confirm is your priority.
Choose 24hrDOC if…
You want an oral route if you will not self-inject and an opening price near $149 a month.
Choose PlushCare if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $149 a month.
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