10rx vs Direct Meds
An in-depth comparison of two leading GLP-1 Providers
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Two GLP-1 Providers chasing the same patients, trading off price, geography and what lands in the box differently. On our scoring, 10rx opens cheaper — $99.67/mo against $249, and Direct Meds is where most people should begin. What follows: the prices, what each plan actually covers, the six-dimension score, where each one is weak, and who should pick which.
Pricing
10rx
Compounded; GLP-1 options as low as under $100/mo
Compounded GLP-1 + GIP
Direct Meds
Portal shows 'As low as $249.00'; inline JSON minMonthly $237 at some dosages; 90-day supply flow (SEMAGLUTIDE_SUB_90_MONTHLY). Unchanged vs our data.
'As low as $297.00 or $9.58 per day'; flow code INT_MTH_084D_3PK (84-day 3-pack billed monthly). Unchanged vs our data.
CHANGED: was $399 in providers.json, now 'As low as $299.00 or $9.65 per day' (TIRZEPATIDE_SUB_90_MONTHLY_3MG_DAY).
'As low as $399.00 or $12.87 per day'; the '$9.58 per day' string on the public /products/tirzepatide marketing page is a copy error (matches sema math). Unchanged vs our data.
What’s included
10rx
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Direct Meds
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
10rx
8.1/10
Direct Meds
6.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 10rx | Direct Meds |
|---|---|---|
| Starting Price | ✓$99.67/mo | $249/mo |
| Features | ✓8 features | 5 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | ✓None | 1 warning |
About 10rx
10rx sets flat monthly rates on compounded GLP-1: semaglutide at $99.67, tirzepatide at $149.67, with NAD+ and sermorelin sold separately for energy and recovery. A free health quiz online reaches a board-certified telehealth doctor, who reads your history before writing anything, and licensed pharmacy partners handle discreet delivery. The company states it reaches every one of the 50 states. What it does not state is its operating company, its pharmacies, or any terms page.
Read our full 10rx review →About Direct Meds
The FDA sent Direct Meds a warning letter in September 2025 over misleading marketing, and customers have reported a documented pattern of unexpected 3-month commitment charges. We list the company with both disclosed in full; read the warnings and the cons first. Its products are compounded semaglutide and tirzepatide, sold from Utah in injection and sublingual form.
Read our full Direct Meds review →Pros & Cons
10rx
What we like
- Semaglutide at $99.67 a month, 47% below the $189 median for the same drug and form across this register
- Tirzepatide at $149.67 a month, 44% below the $267 median for the same drug and form across this register
- Publishes a price on its own site before the medical questionnaire, so it can be compared without handing over health information
- The monthly figure covers medication, consult, shipping
- No FDA warning letter matched this operator when we searched our enforcement register
Watch-outs
- No state list is on record here, so whether it serves your state cannot be confirmed from this page
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Direct Meds
What we like
- Semaglutide at $249 a month, within the normal band around this register's $189 median for the same drug and form
- Publishes a price on its own site before the medical questionnaire, so it can be compared without handing over health information
- The monthly figure covers medication, consult, shipping
Watch-outs
- No state list is on record here, so whether it serves your state cannot be confirmed from this page
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
- 1 FDA warning letter matched to this operator in our enforcement register — read what the letter alleges, since a letter discloses a problem rather than disqualifying a seller
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Direct Meds is the one we would pick, particularly on compounded semaglutide at $249/month. 10rx is a real alternative if semaglutide at $99.67/month, 47% under the register median is what you are after — the six-dimension breakdown and the prices below are what to weigh against your own case.
Choose 10rx if…
You want semaglutide at $99.67/month, 47% under the register median and an opening price near $99.67 a month.
Choose Direct Meds if…
You want compounded semaglutide at $249/month and an opening price near $249 a month.
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Found
Tirzepatide at $169/month, 37% under the register median
From $99/mo
Get started →Telos Rx
Starting below a standard dose, with microdose tiers
From $49/mo
Get started →MyDrHank
An oral route if you will not self-inject
From $25/mo
Get started →10rx vs Direct Meds: FAQ
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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- Direct Meds vs NextMeds
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Or see the full category ranking.
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