GLP Watchdog

RxSpan MD vs Trimrose

Neither RxSpan MD nor Trimrose has an FDA warning letter on record. On compounded tirzepatide injection, RxSpan MD costs $360 less a year at standing rates: $329 a month against $359 a month at Trimrose. It is one of two products the two sell at comparable terms.

By Ruth Calder · Enforcement Editor
Editorially reviewed. Not medical advice · How we verify contentLast reviewed

The record

RxSpan MD / Trimrose

Featured pick (affiliate partner)

RxSpan MD logo

RxSpan MD

7.9/10

Trimrose logo

Trimrose

6.4/10

FDA warning letters
None on record
None on record
Pharmacy
Lowest standing price
$249/moCompounded semaglutide injection
$269/moCompounded semaglutide injection
States
All 50 states
All 50 states
Checked
Prices captured Record checked October 2026
Prices captured Record checked October 2026
Visit RxSpan MDFull review
Visit TrimroseFull review

RxSpan MD is our featured pick on this page because it is an affiliate partner: we are paid if you sign up through our link. Trimrose pays us nothing. The scores are computed the same way for both and are shown as computed (RxSpan MD 7.9, Trimrose 6.4). How we are paid

What the record shows

  1. 01

    Neither RxSpan MD nor Trimrose has an FDA warning letter on record.

  2. 02

    RxSpan MD names four pharmacies. Trimrose names seven pharmacies.

  3. 03

    On compounded tirzepatide injection, RxSpan MD costs $360 less a year at standing rates: $329 a month against $359 a month at Trimrose. It is one of two products the two sell at comparable terms.

  4. 04

    Only RxSpan MD lists a price for brand-name tirzepatide pen. Only Trimrose lists a price for compounded oral semaglutide.

  5. 05

    RxSpan MD states you can cancel at any time; Trimrose does not state its cancellation terms.

Prices and terms, product by product

A price is set against the other side only for the same product, and only when both are standing monthly or 4-week rates. Those pairs are compared by yearly cost.

RxSpan MD

Trimrose

Compounded semaglutide injection

$249/moLower

$2,988 a year

$269/mo

$3,228 a year

Compounded tirzepatide injection

$329/moLower

$3,948 a year

$359/mo

$4,308 a year

Brand-name semaglutide pen

$1,299/mo

$15,588 a year

$1,299/mo

$15,588 a year

Brand-name tirzepatide pen

$1,069/mo

$12,828 a year

Not sold or not priced
Compounded oral semaglutide
Not sold or not priced

$299/mo

$3,588 a year

Price includes
Medication, clinician visits, shipping, coaching
Clinician visits, shipping
Cancel any time
Yes, stated
Not stated
Minimum term
None
None stated (FAQ: no long-term commitments)
Early-exit fee
None stated
Not stated

Read off each seller’s own pages. RxSpan MD: October 17, 2026. Trimrose: October 17, 2026. Every plan and dose we hold is on the full review.

The case for each

The case for RxSpan MD

7.9/10
Featured pick (affiliate partner)
  • $240 a year less on compounded semaglutide injection
  • $360 a year less on compounded tirzepatide injection
  • Sells brand-name tirzepatide pen, which Trimrose does not price
  • States you can cancel at any time
Visit RxSpan MD

The case for Trimrose

6.4/10
  • Sells compounded oral semaglutide, which RxSpan MD does not price
Visit Trimrose

Scores

RxSpan MD 7.9 · Trimrose 6.4 out of 10. Six weighted parts.

Value25%

3.4A
vs
B
4.4

Effectiveness25%

10.0A
vs
B
10.0

User Experience15%

8.0A
vs
B
3.0

Trust & Safety15%

10.0A
vs
B
6.5

Accessibility10%

10.0A
vs
B
10.0

Support10%

8.5A
vs
B
4.0

The score is the same formula for every seller. Payment does not enter it. Method

RxSpan MD vs Trimrose: questions

Neither RxSpan MD nor Trimrose has an FDA warning letter on record. Letters are matched to a seller by company, domain and address, never by a similar name.
RxSpan MD names four pharmacies. Trimrose names seven pharmacies. A 503A pharmacy compounds for named patients on a prescription; a 503B outsourcing facility is registered with FDA and inspected under federal manufacturing rules.
RxSpan MD, by $240 a year at standing rates. RxSpan MD: $249 a month, about $2,988 a year. Trimrose: $269 a month, about $3,228 a year.
RxSpan MD states you can cancel at any time. Trimrose does not state its cancellation terms.
RxSpan MD is our featured pick on this page because it is an affiliate partner: we are paid if you sign up through our link. Trimrose pays us nothing. The scores are computed the same way for both and are shown as computed (RxSpan MD 7.9, Trimrose 6.4).

Other sellers we are paid by

Affiliate partners outside this pair. Each has its own record and review, scored the same way.

Sellers closest to these two

Matched on molecule, form and price. Every pair we list · The register

Brand names on this page are registered marks. Novo Nordisk holds Wegovy®, Ozempic® and Rybelsus®; Eli Lilly holds Zepbound®, Mounjaro® and Foundayo®. Neither company has any tie to GLP Watchdog. Trademarks