Open Water Rx vs NextMeds
An in-depth comparison of two leading GLP-1 Providers
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NextMeds
Best for: semaglutide at $79/month, 59% under the register median
Visit NextMeds →Two GLP-1 Providers chasing the same patients, trading off price, geography and what lands in the box differently. On our scoring, NextMeds opens cheaper — $79/mo against $249, and NextMeds finishes ahead, 9.2 to 6.7. What follows: the prices, what each plan actually covers, the six-dimension score, where each one is weak, and who should pick which.
Pricing
Open Water Rx
Regular $249/mo; $159/mo shown on /pricing and /get-started with code SEMASUMMER. All-inclusive of provider review, medication if prescribed and shipping.
Regular $339/mo; $219/mo with code FOUNDER, which the site describes as locked in 'for life'. A lower-dose titration program is $179/mo and an oral GLP-1 option $279/mo; neither names its molecule, so neither is recorded as a drug row.
NextMeds
Compounded Semaglutide Membership, drug included when prescribed, alongside telehealth visits, a care coach, a dietitian and shipping. $79 is the month-to-month rate read from the pricing section on 2026-08-14. The site headline reads 'from $49/mo': that is the 12-month prepaid term divided down, not a monthly price, and the ladder between them is 3-month $76, 6-month $73, 12-month $49. A summer promotion was running with a stated end of August 20, so $79 may itself be discounted.
Compounded Tirzepatide Membership, drug included when prescribed, alongside telehealth visits, a care coach, a dietitian and shipping. $109 is the month-to-month rate read from the pricing section on 2026-08-14. The advertised 'GLP-1 + GIP: $95' is the 12-month prepaid term divided down; the ladder is 3-month $105, 6-month $100, 12-month $95. A summer promotion was running with a stated end of August 20, so $109 may itself be discounted.
What’s included
Open Water Rx
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
NextMeds
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
In the price
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Open Water Rx
6.7/10
NextMeds
9.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Open Water Rx | NextMeds |
|---|---|---|
| Starting Price | $249/mo | ✓$79/mo |
| Features | 0 features | ✓8 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About Open Water Rx
Open Water Rx describes itself as a telehealth platform for GLP-1 weight loss and longevity, per its own site. Nothing else is surfaced publicly: not the medications, the pricing, the states served, the pharmacy partner or the clinical leadership. This entry exists mainly to confirm the brand and its category. Verify specifics directly with the seller before enrolling.
Read our full Open Water Rx review →About NextMeds
Membership is a single flat monthly charge, and inside it sit free shipping, a registered dietitian holding a license, a care coach working 1:1, telehealth visits and the drug itself where one is prescribed. Insurance is not billed. A free assessment online goes to a licensed provider, who adds a phone or video consult in states that demand one, then prescribes if it fits. Compounding pharmacies within the Next Meds network, all licensed, ship. Auto-renewal does not exist, cancellation is open, and all 50 states can order compounded tirzepatide and semaglutide.
Read our full NextMeds review →Pros & Cons
Open Water Rx
What we like
- Semaglutide at $249 a month, within the normal band around this register's $189 median for the same drug and form
- Publishes a price on its own site before the medical questionnaire, so it can be compared without handing over health information
- The monthly figure covers medication, consult, shipping
- No FDA warning letter matched this operator when we searched our enforcement register
Watch-outs
- No state list is on record here, so whether it serves your state cannot be confirmed from this page
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
NextMeds
What we like
- Semaglutide at $79 a month, 58% below the $189 median for the same drug and form across this register
- Tirzepatide at $109 a month, 59% below the $267 median for the same drug and form across this register
- Publishes a price on its own site before the medical questionnaire, so it can be compared without handing over health information
- The monthly price is recorded as flat across doses, so it does not climb as the dose is titrated up
- The monthly figure covers medication, consult, shipping, coaching
- Coverage is published for all 50 states
- No FDA warning letter matched this operator when we searched our enforcement register
Watch-outs
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
NextMeds takes it, 9.2 against 6.7, and it is especially strong on semaglutide at $79/month, 59% under the register median. Open Water Rx is no weak second and may fit you better on compounded semaglutide at $249/month.
Choose Open Water Rx if…
You want compounded semaglutide at $249/month and an opening price near $249 a month.
Choose NextMeds if…
You want semaglutide at $79/month, 59% under the register median and an opening price near $79 a month.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
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SkinnyRx
Starting below a standard dose, with microdose tiers
From $149.25/mo
Get started →Trimi Health
Knowing which pharmacy fills the vial — it names VialsRx
From $99/mo
Get started →Strut Health
Semaglutide at $99/month, 48% under the register median
From $99/mo
Get started →Open Water Rx vs NextMeds: FAQ
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring Open Water Rx and NextMeds head-to-heads in the same category.
- Open Water Rx vs Trimi Health
- Open Water Rx vs Embody
- Open Water Rx vs He & She MD
- NextMeds vs Lean Meds
- NextMeds vs bmiMD
- NextMeds vs CoreAge Rx
Or see the full category ranking.
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