LifeMD vs Piper
Piper costs $14 less a month, and both sell semaglutide and tirzepatide.
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LifeMD
Best for: bloodwork inside the monthly price rather than billed on top
Visit LifeMD →
Piper
Best for: coverage in all 50 states, which most sellers will not confirm
Visit Piper →If you are choosing between LifeMD and Piper, the first difference is cost: Piper is $14 a month cheaper at the entry price. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. LifeMD leads our six-part score, 7.9 to 7.4.
LifeMD vs Piper price
Piper is the cheaper way in: $135 a month against $149 a month at LifeMD. That is $14 less each month (9% lower), or about $168 over a year of treatment.
Drug by drug: Semaglutide is cheaper at Piper ($135 a month vs $149 a month); tirzepatide is cheaper at Piper ($199 a month vs $349 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format, LifeMD prices brand-name pens, while Piper prices compounded injections.
If you want the FDA-approved brand rather than a compounded version, LifeMD is the only one of the two with a brand-name price.
Where each one treats patients
LifeMD lists 50 states, and Piper lists 50 states.
They overlap in 50 states.
Pricing
LifeMD
First month $75, then $149/mo. Brand medication billed separately, or $0-$25/mo copay with commercial insurance.
Medication only; plus the $149/mo program fee.
Medication only (starting); plus the program fee. As low as $0-$25/mo with insurance.
Medication only; plus the $149/mo program fee.
Piper
What each price covers
Both prices cover the clinician visit.
LifeMD's price also covers lab work and coaching, which Piper does not claim.
Piper's price also covers the medication itself and shipping, which LifeMD does not claim.
LifeMD is silent on shipping.
Piper is silent on lab work and coaching.
That matters most for the drug: unless LifeMD confirms otherwise, budget for medication on top of its listed price.
LifeMD
Covered by the monthly price
Medication
Charged on top
Clinician visits
In the price
Shipping
Not stated
Lab work
In the price
Coaching
In the price
Piper
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, LifeMD scores 7.9 and Piper 7.4 out of 10.
LifeMD is stronger on value (10.0 vs 3.0).
Piper is stronger on user experience (8.0 vs 3.0), trust & safety (8.5 vs 6.0) and support (7.0 vs 5.5).
Effectiveness and accessibility are within half a point.
LifeMD
7.9/10
Piper
7.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither LifeMD nor Piper has an FDA warning letter on record with us.
Features & Coverage
| Feature | LifeMD | Piper |
|---|---|---|
| Starting Price | $149/mo | ✓$135/mo |
| Features | 0 features | ✓3 features |
| States Available | 50 | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | None | None |
About LifeMD
LifeMD is a publicly traded telehealth seller. It carries brand-name GLP-1 medications only.
Read our full LifeMD review →About Piper
Piper is a telehealth weight loss seller offering compounded GLP-1 medications at competitive prices.
Read our full Piper review →Pros & Cons
LifeMD
What we like
- Semaglutide costs $149 a month, 85% below the $990 median for brand-name semaglutide across the sellers we compare
- Tirzepatide costs $349 a month, 72% below the $1249 median for brand-name tirzepatide across the sellers we compare
- The monthly price includes clinician visits, lab work and coaching
- Serves all 50 states
- We found no FDA warning letters issued to LifeMD
Watch-outs
- You only see a price after finishing the medical intake, so you cannot compare costs before sharing health information
- Not included in the monthly price: medication
- Ask which pharmacy fills the prescription before you pay, so you can check its license
Piper
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price stays the same as your dose goes up
- The monthly price includes the medication, clinician visits and shipping
- Serves all 50 states
- We found no FDA warning letters issued to Piper
Watch-outs
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
LifeMD wins this one, 7.9 to 7.4, above all for bloodwork inside the monthly price rather than billed on top. Piper undercuts it by $14 a month, so if the monthly bill is what decides it, Piper is the pick. Piper fits better if coverage in all 50 states, which most sellers will not confirm is your priority.
Choose LifeMD if…
You want bloodwork inside the monthly price rather than billed on top and an opening price near $149 a month.
Choose Piper if…
You want coverage in all 50 states, which most sellers will not confirm and an opening price near $135 a month.
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Wellorithm
Compounded semaglutide at $247/month
From $247/mo
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Seeing what it charges before you answer any medical questions
From $299/mo
Get started →Sesame Care
Oral orforglipron alongside the injectables
From $59/mo
Get started →LifeMD vs Piper: FAQ
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