Fifty 410 vs NextMeds
An in-depth comparison of two leading GLP-1 Providers
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Fifty 410
Best for: semaglutide at $99/month, 50% under the register median
Visit Fifty 410 →
NextMeds
Best for: semaglutide at $79/month, 59% under the register median
Visit NextMeds →Two GLP-1 Providers chasing the same patients, trading off price, geography and what lands in the box differently. On our scoring, NextMeds opens cheaper — $79/mo against $99, and NextMeds finishes ahead, 9.2 to 7.9. What follows: the prices, what each plan actually covers, the six-dimension score, where each one is weak, and who should pick which.
Pricing
Fifty 410
NextMeds
Compounded Semaglutide Membership, drug included when prescribed, alongside telehealth visits, a care coach, a dietitian and shipping. $79 is the month-to-month rate read from the pricing section on 2026-08-14. The site headline reads 'from $49/mo': that is the 12-month prepaid term divided down, not a monthly price, and the ladder between them is 3-month $76, 6-month $73, 12-month $49. A summer promotion was running with a stated end of August 20, so $79 may itself be discounted.
Compounded Tirzepatide Membership, drug included when prescribed, alongside telehealth visits, a care coach, a dietitian and shipping. $109 is the month-to-month rate read from the pricing section on 2026-08-14. The advertised 'GLP-1 + GIP: $95' is the 12-month prepaid term divided down; the ladder is 3-month $105, 6-month $100, 12-month $95. A summer promotion was running with a stated end of August 20, so $109 may itself be discounted.
What’s included
Fifty 410
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
NextMeds
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
In the price
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Fifty 410
7.9/10
NextMeds
9.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Fifty 410 | NextMeds |
|---|---|---|
| Starting Price | $99/mo | ✓$79/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | ✓ Yes | ✓ Yes |
| FDA Warnings | 1 warning | ✓None |
About Fifty 410
Pricing is public and transparent: compounded semaglutide from 99 dollars a month, a tirzepatide starter at 133 dollars a month, and a high-dose tier above those. There is no membership; billing is pay-as-you-go. Shipping is free and lands in one to two days, after a provider review that takes 24 to 48 hours. Licensed providers prescribe the personalized medication and FDA-registered 503A and 503B pharmacies prepare it. Fifty 410 is cash-pay only and bills no insurance directly, but takes Affirm, Afterpay and FSA/HSA.
Read our full Fifty 410 review →About NextMeds
Membership is a single flat monthly charge, and inside it sit free shipping, a registered dietitian holding a license, a care coach working 1:1, telehealth visits and the drug itself where one is prescribed. Insurance is not billed. A free assessment online goes to a licensed provider, who adds a phone or video consult in states that demand one, then prescribes if it fits. Compounding pharmacies within the Next Meds network, all licensed, ship. Auto-renewal does not exist, cancellation is open, and all 50 states can order compounded tirzepatide and semaglutide.
Read our full NextMeds review →Pros & Cons
Fifty 410
What we like
- Semaglutide at $99 a month, 48% below the $189 median for the same drug and form across this register
- Tirzepatide at $133 a month, 50% below the $267 median for the same drug and form across this register
- Publishes a price on its own site before the medical questionnaire, so it can be compared without handing over health information
- The monthly figure covers medication, consult, shipping
Watch-outs
- No state list is on record here, so whether it serves your state cannot be confirmed from this page
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
- 1 FDA warning letter matched to this operator in our enforcement register — read what the letter alleges, since a letter discloses a problem rather than disqualifying a seller
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
NextMeds
What we like
- Semaglutide at $79 a month, 58% below the $189 median for the same drug and form across this register
- Tirzepatide at $109 a month, 59% below the $267 median for the same drug and form across this register
- Publishes a price on its own site before the medical questionnaire, so it can be compared without handing over health information
- The monthly price is recorded as flat across doses, so it does not climb as the dose is titrated up
- The monthly figure covers medication, consult, shipping, coaching
- Coverage is published for all 50 states
- No FDA warning letter matched this operator when we searched our enforcement register
Watch-outs
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
NextMeds takes it, 9.2 against 7.9, and it is especially strong on semaglutide at $79/month, 59% under the register median. Fifty 410 is no weak second and may fit you better on semaglutide at $99/month, 50% under the register median.
Choose Fifty 410 if…
You want semaglutide at $99/month, 50% under the register median and an opening price near $99 a month.
Choose NextMeds if…
You want semaglutide at $79/month, 59% under the register median and an opening price near $79 a month.
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Telos Rx
Starting below a standard dose, with microdose tiers
From $49/mo
Get started →MyDrHank
An oral route if you will not self-inject
From $25/mo
Get started →SkinnyRx
Starting below a standard dose, with microdose tiers
From $149.25/mo
Get started →Fifty 410 vs NextMeds: FAQ
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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