1st Optimal vs MD Trim Clinic
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: coaching bundled into the price rather than sold separately
Visit 1st Optimal →
MD Trim Clinic
Best for: a published state list — 2 of 50 — when most of the register publishes none
Visit MD Trim Clinic →Two GLP-1 Providers chasing the same patients, trading off price, geography and what lands in the box differently. On our scoring, they finish level on 3.9. What follows: the prices, what each plan actually covers, the six-dimension score, where each one is weak, and who should pick which.
What’s included
1st Optimal
Covered by the monthly price
Medication
Not stated
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
In the price
MD Trim Clinic
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Charged on top
Coaching
Charged on top
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
3.9/10
MD Trim Clinic
3.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | MD Trim Clinic |
|---|---|---|
| Starting Price | — | — |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 2 |
| Compounded | — | — |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
Neither a monthly price nor a list of states is published. 1st Optimal operates out of Michigan across telehealth and functional medicine, writing the GLP-1s semaglutide and tirzepatide either as a weekly injection or as a daily oral tablet. Around the prescription it stacks at-home lab testing, interpretation of the blood work, coaching without limit and protocols built individually, all framed as long-term weight loss and longevity. Credentialed providers work virtually, treatment goes to the home, and nothing binds you to a long contract.
Read our full 1st Optimal review →About MD Trim Clinic
Weekly dose sets the program tier, Level 1 or Level 2, and the compounded semaglutide and tirzepatide are dispensed by LegitScript-certified pharmacies that add B12 to reduce nausea. MD Trim Clinic is small and physician-led, with offices in Novato, CA and Phoenix, AZ, seeing patients in person and by telehealth. Its leads are nurse practitioner Andrea Farris, N.P. and Dr. Brandon Shaw, D.O. Initial screening is free, titration of dosing is physician-guided, and team support is ongoing.
Read our full MD Trim Clinic review →Pros & Cons
1st Optimal
What we like
- The monthly figure covers consult, shipping, coaching
- No FDA warning letter matched this operator when we searched our enforcement register
- A live video visit with a clinician is required before a prescription, which is slower than a form and is the more careful intake
- Baseline bloodwork is required before a prescription
Watch-outs
- No price appears until the medical intake is complete, so the cost cannot be compared before health information is submitted
- No state list is on record here, so whether it serves your state cannot be confirmed from this page
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
MD Trim Clinic
What we like
- The monthly figure covers medication, consult, shipping
- No FDA warning letter matched this operator when we searched our enforcement register
Watch-outs
- No price appears until the medical intake is complete, so the cost cannot be compared before health information is submitted
- Billed separately from the monthly figure: labs, coaching
- Coverage is published for 2 states only, so this may not reach you
- No dispensing pharmacy is named in our record, so its accreditation cannot be looked up from here
Our Verdict
Both 1st Optimal and MD Trim Clinic score equally well overall — the right choice depends on your priorities.
Choose 1st Optimal if…
You want coaching bundled into the price rather than sold separately.
Choose MD Trim Clinic if…
You want a published state list — 2 of 50 — when most of the register publishes none.
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Trimi Health
Knowing which pharmacy fills the vial — it names VialsRx
From $99/mo
Get started →Strut Health
Semaglutide at $99/month, 48% under the register median
From $99/mo
Get started →Oak
Semaglutide at $119/month, 37% under the register median
From $119/mo
Get started →1st Optimal vs MD Trim Clinic: FAQ
Glossary
The words sellers use, defined. Tap any term.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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