MadeMed vs Synergy Rx
Synergy Rx costs $20 less a month, and both sell semaglutide and tirzepatide.
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Synergy Rx
Best for: knowing which pharmacy fills the vial: it names Belmar Pharmacy
Visit Synergy Rx →If you are choosing between MadeMed and Synergy Rx, the first difference is cost: Synergy Rx is $20 a month cheaper at the entry price. Both prescribe semaglutide and tirzepatide, so moving from one to the other would not change your drug. Synergy Rx leads our six-part score, 7.5 to 6.5.
MadeMed vs Synergy Rx price
Synergy Rx is the cheaper way in: $199 a month against $219 a month on a prepaid plan at MadeMed. That is $20 less each month (9% lower), or about $240 over a year of treatment.
MadeMed's figure is a monthly average of a plan billed for several months at once, so the first charge is larger than the number shown.
Drug by drug: Semaglutide is cheaper at Synergy Rx ($199 a month vs $219 a month on a prepaid plan); tirzepatide is cheaper at MadeMed ($299 a month on a prepaid plan vs $349 a month).
Medications and formats
Both sell semaglutide and tirzepatide.
On format they match: each offers compounded injections and an oral option.
Where each one treats patients
MadeMed does not publish where it ships, and Synergy Rx lists 50 states.
Pricing
MadeMed
Quarterly plan $239/mo (billed $717/3mo); 6-month plan drops to $199/mo (the site's 'From $199/mo'). Includes L-Carnitine; 2-month supplies.
Quarterly $399/mo (billed $1,197/3mo); 6-month $369/mo.
Quarterly $219/mo (billed $657/3mo); 6-month $179/mo. Includes B6.
Quarterly $299/mo (billed $897/3mo); 6-month $279/mo.
Synergy Rx
$100 welcome credit auto-applied at checkout site-wide; free shipping
$100 above tirz median $249
What each price covers
Synergy Rx's price also covers the clinician visit, the medication itself and shipping, which MadeMed does not claim.
MadeMed does not say what its price includes.
Synergy Rx is silent on lab work and coaching.
That matters most for the drug: unless MadeMed confirms otherwise, budget for medication on top of its listed price.
MadeMed
Inclusions not disclosed.
Synergy Rx
Covered by the monthly price
Medication
In the price
Clinician visits
In the price
Shipping
In the price
Lab work
Not stated
Coaching
Not stated
Where each one scores higher
Overall, Synergy Rx scores 7.5 and MadeMed 6.5 out of 10.
Synergy Rx is stronger on trust & safety (9.0 vs 6.5), accessibility (10.0 vs 5.0) and support (7.0 vs 5.0).
Value, effectiveness and user experience are within half a point.
MadeMed
6.5/10
Synergy Rx
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
FDA warning letters
Neither MadeMed nor Synergy Rx has an FDA warning letter on record with us.
Features & Coverage
| Feature | MadeMed | Synergy Rx |
|---|---|---|
| Starting Price | $219/mo prepaid | ✓$199/mo |
| Features | 6 features | 6 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warning Letters | None | None |
About MadeMed
Nothing is priced in public at MadeMed; the number waits inside the product pages or the checkout. Its catalog runs to four distinct products, compounded semaglutide and compounded tirzepatide, each offered as an injection or by mouth, so patients who dislike needles get more choice here than most rivals allow. A LegitScript certification badge is displayed, and unlike chat-only competitors it publishes a phone line for support.
Read our full MadeMed review →About Synergy Rx
Synergy Rx (on its CareGLP platform) is a Wyoming-registered telehealth platform that by its own account serves 50,000+ patients. Compounded semaglutide is $199 and tirzepatide $349; brand-name Ozempic is $499, with Wegovy and Mounjaro at $947 each. It runs on the same shared Lion MD clinician and 4-pharmacy network as Breeze Meds and Care Bare Rx.
Read our full Synergy Rx review →Pros & Cons
MadeMed
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- We found no FDA warning letters issued to MadeMed
Watch-outs
- Semaglutide costs $239 a month, 30% above the $184 median for compounded semaglutide across the sellers we compare
- Tirzepatide costs $399 a month, 60% above the $250 median for compounded tirzepatide across the sellers we compare
- Confirm it serves your state before you start the intake
- Ask which pharmacy fills the prescription before you pay, so you can check its license
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Synergy Rx
What we like
- Shows its price before the medical questionnaire, so you can compare it without handing over health information
- The monthly price includes the medication, clinician visits and shipping
- Serves all 50 states
- Names 4 pharmacies that fill its prescriptions, which most sellers do not
- We found no FDA warning letters issued to Synergy Rx
Watch-outs
- Its semaglutide and tirzepatide are compounded rather than FDA-approved, so they have not been reviewed by the agency for safety, effectiveness or manufacturing quality
Our Verdict
Synergy Rx wins this one, 7.5 to 6.5, above all for knowing which pharmacy fills the vial: it names Belmar Pharmacy. It also costs $20 less each month than MadeMed. MadeMed fits better if compounded semaglutide at $239/month is your priority.
Choose MadeMed if…
You want compounded semaglutide at $239/month and an opening price near $219 a month.
Choose Synergy Rx if…
You want knowing which pharmacy fills the vial: it names Belmar Pharmacy and an opening price near $199 a month.
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Found
Tirzepatide at $169/month, 37% below the typical price
From $149/mo
Get started →Breeze Meds
Knowing which pharmacy fills the vial: it names Belmar Pharmacy
From $199/mo
Get started →HealthRX
Compounded semaglutide at $133/month
From $133/mo
Get started →MadeMed vs Synergy Rx: FAQ
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- MadeMed vs Breeze Meds
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- Synergy Rx vs HumeCare+
- Synergy Rx vs Ascend Vitality
Or see the full category ranking.