Mounjaro Dosing & Titration Schedule
Where tirzepatide begins, every step it climbs, and where it stops — maintenance and maximum both — read straight off the FDA prescribing information.
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Mounjaro Titration Schedule
Each rung of the Mounjaro ladder, taken from Dosage & Administration in its FDA label (DailyMed SetID d2d7da5d-ad07-4228-955f-cf7e355c8cc0). The schedule you actually follow is the one your prescriber writes; this is the reference behind it, not advice about your case.
| Step | Dose | When |
|---|---|---|
| 1 | 2.5 mg once weekly | Weeks 1–4 — a run-in dose, not one that controls blood sugar |
| 2 | 5 mg once weekly | Once 4 weeks at 2.5 mg are behind you |
| 3 | Increase in 2.5 mg increments (7.5 / 10 / 12.5 / 15 mg) | 4 weeks or more at the current dose, if blood sugar needs more |
Source: Mounjaro FDA prescribing information via DailyMed (SetID d2d7da5d-ad07-4228-955f-cf7e355c8cc0), Section 2 Dosage & Administration, read on 2026-06-01. Treat this as a summary: the full label is the document, and your prescriber's instructions are what you follow.
Mounjaro Dosing at a Glance
How to titrate safely
Steps come in 2.5 mg increments, and never sooner than 4 weeks at the current dose. Inject once a week at whatever hour suits, fed or fasted; you may move which weekday you use as long as 72 hours separate the two doses.
One rule governs the whole ladder: you only climb if you are tolerating where you already are, and you hold or slow down when side effects flare. Outrunning the label's schedule does not get you results sooner. What it reliably produces is more nausea and more of everything else the gut does in response.
If you miss a dose or can't tolerate a step
Missed a dose? How late is too late is not the same answer for every drug. Read GLP-1 missed-dose rules by drug for what Mounjaro specifically allows, before you double up or write the dose off.
Can't tolerate a dose increase? Holding at the current dose, or waiting longer before the next step, is something the label explicitly permits. What each step tends to bring is set out on the Mounjaro side effects page, then talk to your prescriber before changing your schedule.
Compare every Mounjaro provider
Your dose and your titration plan are set by a prescriber before anything is written. Current price, verification status, product form and the states each seller ships to are all on one screen.